An analysis of data on the use of radiation therapy in a large clinical trial of patients with HR+, HER2- breast cancer who had one to three involved lymph nodes and a 21-gene recurrence score of 25 or less found that rates of locoregional recurrence of the disease were low regardless of whether a patient had received regional node irradiation (RNI). The results suggest that a randomized clinical trial is required to answer the question of whether these favorable-risk patients can safely skip RNI.
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