The gastric corpus, which is a major component of the glandular stomach, is composed of parietal, chief, pit, and neck cells. Each of these specialized epithelial cells play an important role in digestion, and they are continuously replenished by new ones which are formed via the differentiation of stem cells. Defects in this process lead to gastric diseases such as intestinal metaplasia and gastric cancer. However, the underlying mechanisms responsible for the renewal and differentiation of stem cells, and thus the maintenance of gastric homeostasis, have yet to be explained.
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