A team led by Prof. Li Yu from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences (CAS), in collaboration with Prof. Fu Wenguang and Prof. Fang Jing, identified a novel mechanism for the HIF prolyl hydroxylase domain protein 3 (PHD3)-dependent proline hydroxylation of cAMP responsive element binding protein (CREB)-regulated transcriptional coactivator 2 (CRTC2) in the regulation of hepatic gluconeogenesis. This study was published online in PNAS on May 30.
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