Sensory neurons play a crucial role in the perception of "hot" and "cold". They express a group of ion channels called thermosensitive TRP channels. For example, TRPV1 (activated above 43°C) and TRPM8 (activated below 29°C) send the "hot" and "cold" information to our brains, respectively, for which the 2021 Nobel Prize in Physiology or Medicine was awarded.
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