Immunotherapy is a highly effective treatment for patients whose cancers harbor mismatch repair deficiency, and a new study identifies more cancer patients who could benefit from this form of therapy. Investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham health care system, found that nearly six percent of endometrial cancer patients and one percent of colorectal cancer patients with mismatch repair deficiency were missed by immunohistochemistry, the current standard of care test for this condition. In these missed cases, the condition was instead detected by next-generation sequencing, which researchers estimate could identify 6,000 additional patients in the U.S. who would otherwise not be offered immunotherapy. Results are published in the journal Cancer Cell.
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