Early in 2024, reports of a fatal case of Alaskapox were circulating in the news. A little-known virus with few cases to its name, Alaskapox virus triggers the eruption of 1 or more skin lesions on the body, among other symptoms. The virus is just 1 of many orthopoxviruses—some, like smallpox and mpox, with much higher disease burdens—whose modus operandi is the formation of skin lesions.
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