Sustained hypoxia affects orthodontic tooth movement (OTM) by altering osteoclast and osteoblast differentiation, report researchers from the Institute of Science Tokyo, Japan. Hypoxic conditions resulted in reduced alveolar bone levels after OTM and lower expression of runt-related transcription factor 2 and vascular endothelial growth factor. These findings, observed in a rat model, provide critical insights into the bone remodeling process in OTM under hypoxia.
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